The long-term safety profile of semaglutide is encouraging. The most common side effects of semaglutide are nausea, diarrhea, constipation, vomiting, abdominal pain and headache. In most cases, these side effects improve as your body adjusts to the medication. However, some people experience more severe or persistent symptoms that require adjusting their dose or stopping treatment altogether. There are also some potential long-term risks associated with semaglutide use, although more research is needed to fully understand these effects. These may include:
- Pancreatitis (inflammation of the pancreas)
- Gallbladder problems
- Increased risk of thyroid tumors (seen in animal studies)
- Changes in kidney function
- Interactions with other medications